SNP Genetics (Korea)

An antisense oligonucleotide (ASO) is a short (usually ~12–25 nucleotides) strand of synthetic nucleic acid designed to bind a specific RNA sequence by Watson Crick base pairing. Once bound, an ASO can change gene expression in several ways depending on its chemistry and design: it can trigger RNase H-mediated cleavage of the target mRNA (reducing protein production), sterically block translation, alter pre-mRNA splicing (splice-switching ASOs), or modulate microRNA activity. ASOs are sequence-s

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An antisense oligonucleotide (ASO) is a short (usually ~12–25 nucleotides) strand of synthetic nucleic acid designed to bind a specific RNA sequence by Watson Crick base pairing. Once bound, an ASO can change gene expression in several ways depending on its chemistry and design: it can trigger RNase H-mediated cleavage of the target mRNA (reducing protein production), sterically block translation, alter pre-mRNA splicing (splice-switching ASOs), or modulate microRNA activity. ASOs are sequence-s

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