Daan Gene

文章来源:赢享分子诊断公众号(ID: daangenescb)近日,达安基因自主研发的人类ALDH2基因分型检测试剂盒(PCR-荧光探针法)(国械注准20253402003)获得国家药品监督管理局颁发的三类医疗器械注册证,正式上市!该产品基于荧光PCR技术,体外定性检测人全血样本基因组DNA中ALDH2基因G1510A(rs671)位点多态性;检测范围广,可准确检测0.5-150ng/µL的核酸;同时添加了防污染组分,进而减少因PCR产物引起的污染。通过检测ALDH2基因多态性,可以指导硝酸甘油的个体化用药,评估个体酒精代谢能力,以及识别相关疾病的高风险人群,进而降低疾病的发生率。随着新产品的重磅上市,达安基因在药物基因学与个体化用药检测领域解决方案持续完善。 ALDH2基因多态性 乙醛脱氢酶2(aldehyde dehydrogenase 2, ALDH2)是线粒体内一种重要的代谢酶,同时具有乙醛脱氢酶和酯酶活性,参与乙醇、硝酸甘油等在体内的代谢。ALDH2基因具有遗传多态性,其中以12号外显子上的SNP位点G1510A(rs671)研究最为广泛。ALDH2基因G1510

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